The Brasch Group

Publications

Vitamin B₁₂ and redox homeostasis: Cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)

Suarez-Moreira, E.; Yun, J.; Birch, C. S.; Williams, J. H. H.; McCaddon, A.; Brasch, N. E.*, J. Am. Chem. Soc, 2009, 131(42), 15078.

(Download)

Mechanistic Studies on the Reaction between R₂N-NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl (NO^-) Group from R₂N-NONOates to Cobalt(III) Centers

Hassanin, H. A.; Hannibal, L.; Jacobsen, D. W.; El-Shahat, M. F.; Hamza, M. S. A and Brasch, N. E.*, Angew. Chemie Int. Ed., 2009, 48(47), 8909.

(Download)

Synthesis, Synchrotron X-ray Diffraction and Kinetic Studies on the Formation of a Novel Thiolatocobalamin of Captopril: Evidence for cis-trans isomerization in the β-axial Ligand

Mukherjee, R.; McCaddon, A.; Smith, C. A.; Brasch, N. E.*, Inorg. Chem., 2009, 48(19), 9526.

(Download)

High Resolution Crystal Structure Determination of the Methylcobalamin Analogs Ethylcobalamin and Butylcobalamin by X-ray Synchrotron Diffraction

Hannibal. L.; Smith, C. A.; Smith, J. A.; Axhemi, A.; Miller,A.; Wang, S.; Brasch, N. E. and Jacobsen, D. W.*, Inorg. Chem., 2009, 48(14), 6615.

(Download)

A Novel Role for Vitamin B₁₂: Cobalamins are Potent Intracellular Antioxidants

Birch, C. S.; Brasch, N. E.; McCaddon, A. and Williams, J. H. H.*, Free Rad. Biol, Med., 2009, 47(2), 184.

(Download)

Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product

Hannibal, L.; Kim, J.; Brasch, N. E.; Wange, S.; Rosenblatt, D. S.; Banerjee, R.; Jacobsen, D. W.* Mol. Gen. Metab. 2009, 97, 260.

(Download)

NMR Spectroscopy and Molecular Modelling Studies of Nitrosylcobalamin: Further Evidence that the Deprotonated, Base-off Conformation is an Important Conformation of Nitrosylcobalamin in Solution

Hassanin, H. A.; Hannibal, L.; Jacobsen, D. W.; Brown, K. L.; Marques, H. L.* and Brasch, N. E.*, Dalton Trans. 2009, 424 (selected for the journal cover and selected as a “Hot Article”).

(Download)

Accurate Assessment and Identification of Naturally Occurring Cellular Cobalamins

Hannibal, L.; Axhemi, A.; Glushchenko, A. V.; Suarez-Moreira, E.; Brasch, N. E.*; Jacobsen, D. W.*, Clin. Chem. Lab. Med. 2008, 46, 1739.

(Download)

Vanadium-Vitamin B₁₂ Bioconjugates as Potential Therapeutics for Treating Diabetes

Mukherjee, R.; Donnay, E. G.; Radomski, M. A.; Miller, C.; Redfern, D. A.; Gericke, A.; Damron, D. S.; Brasch, N. E.* Chem. Commun. 2008, 3783.

(Download)

Synthesis and X-ray structural characterization of tris(L-glycinato)vanadium(III) and trans-tetraquadichlorovanadium(III) chloride

Fry, F. H.;* Dougan, B.; McCann, N.; Willis, A. C.; Ziegler, C. J.; Brasch, N. E.* Inorg. Chim. Acta 2008, 2321.

(Download)

Nitroxylcob(III)alamin: Synthesis and X-ray Structural Characterization

Hannibal, L.; Smith, C. A.; Jacobsen, D. W.; Brasch, N. E.* Angew. Chem. 2007, 46, 5140.

(Download)

X-ray Structural Characterization of Imidazolylcobalamin and Histidinylcobalamin: Cobalamin Models for Aquacobalamin Bound to the B₁₂ Transporter Protein Transcobalamin

Hannibal, L.; Bunge, S. D.; van Eldik, R.; Jacobsen, D. W.; Kratky, C.; Gruber, K.;* Brasch, N. E.* Inorg. Chem. 2007, 46, 3613.

(Download)

Structural and Spectroscopic Evidence for Formation of Trinuclear and Tetranuclear V(III)/Carboxylate Complexes of Acetate and Related Derivatives in Aqueous Solution

Mukherjee, R.; Dougan, B. A.; Fry, F. H.; Bunge, S. D.; Ziegler, C. J.; Brasch, N. E.* Inorg. Chem. 2007, 46, 1575.

(Download)

A Simple, Convenient Method to Synthesize Cobalamins: Synthesis of Homocysteinylcobalamin, N-Acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, Sulfitocobalamin and Nitrocobalamin

Suarez-Moreira, E.; Hannibal, L.; Smith, C. A.; Chavez, R. A.; Jacobsen, D. W. and Brasch, N. E.* Dalton Trans. 2006, 5269.

(Download)

Characterization of Novel Vanadium(III)/Acetate Clusters Formed in Aqueous Solution

Fry, F. H.; Dougan, B. A.; McCann, N.; Ziegler, C. J.; Brasch, N. E.* Inorg. Chem. 2005, 44, 5197.

(Download)

Ligand Exchange on Phosphenium Ions: Reversible Exchange between Free and Coordinated Alkynes in Phosphirenium Salts

Brasch, N. E.;* Hamilton, I. G.; Krenske, E. H.; Wild, S. B.*Organomet. 2004, 23, 299.

(Download)

Studies on the Formation of Glutathionylcobalamin: Any Free Intracellular Aquacobalamin is Likely to be Rapidly and Irreversibly Converted to Glutathionylcobalamin

Xia, L.; Cregan, A. G.; Berben, L. A.; Brasch, N. E.* Inorg. Chem. 2004, 43, 6848.

(Download)

Method of synthesis of β-thiolato cobalamin nucleoside compounds

Brasch, N. E.*; Xia, L., U.S. Patent Appl. 20040054128, 2004.

(Download)

A Novel Redox Mechanism for the Glutathione-dependent Reversible Uptake of a Fungal Toxin in Cells

Bernado, P. H.; Brasch, N.; Chai, C. L. L.; Waring, P.*J. Biol. Chem.2003, 278, 46549.

(Download)

The Reaction Between Methylcobalamin and Cyanide Revisited

Brodie, S. F.; Cregan, A. G.; van Eldik, R.; Brasch, N. E.* Inorg. Chim. Acta 2003, 348, 221.

(Download)

Mechanistic Insight from Activation Parameters for the Reaction between Coenzyme B₁₂ and Cyanide: Further Evidence that Heterolytic Co-C Bond Cleavage is Solvent-Assisted

Hamza, M. S. A.; Cregan, A. G.; Brasch, N. E.*; van Eldik, R.* Dalton Trans. 2003, 596.

(Download)

Studies on the Mechanism of the Reaction between 5′-Deoxyadenosylcobinamide and Cyanide

Brasch, N. E.*; Cregan, A. G.; Vanselow, M. L. Dalton Trans. 2002, 1287.

(Download)

Synthesis, Characterization, Solution Stability and X-ray Crystal Structure of the Thiolatocobalamin γ-Glutamylcysteinylcobalamin, a Dipeptide Analog of Glutathionylcobalamin: Insights Into the Enhanced Co-S Bond Stability of the Natural Product Glutathionylcobalamin

Suto, R. K.; Brasch, N. E.; Anderson, O. P.; Finke, R. G.* Inorg. Chem. 2001, 40, 2686.

(Download)

Thermodynamic and Kinetic Studies on the Reaction between the Vitamin B₁₂ Derivative β-(N-Methylimidazolyl)cobalamin and N-Methylimidazole: Ligand Displacement at the α Axial Site of Cobalamins

Cregan, A. G.; Brasch, N. E.;* van Eldik, R.* Inorg. Chem. 2001, 40, 1430.

(Download)

Studies on the Mechanism of the Reaction Between Coenzyme B₁₂ and Cyanide: Direct ¹H NMR Spectroscopic Evidence for a (β-5′-Deoxyadenosyl)(α-cyano)cobalamin Intermediate

Brasch, N. E.;* Haupt, R. J. Inorg. Chem. 2000, 39, 5469.

(Download)

A Simple, Convenient and Direct Method for Assessing the Purity of Cobalamins

Brasch, N. E.; Finke, R. G.*J. Inorg. Biochem. 1999, 73, 215.

(Download)

Synthesis and Characterization of Isolable Thiolatocobalamin Complexes Relevant to Coenzyme B₁₂-Dependent Ribonucleotide Triphosphate Reductase

Brasch, N. E.; Hsu, T.-L. C.; Doll, K.; Finke, R. G.* J. Inorg. Biochem. 1999, 76, 197.

(Download)

The Second Isolable B₁₂-Thiolate Complex, (Pentafluorophenylthiolato)cobalamin: Synthesis and Characterization

Hsu, T.-L. C.; Brasch, N. E.; Finke, R. G.* Inorg. Chem. 1998, 37, 5109.

(Download)

¹⁷O NMR Study of Solvent Exchange in Some Aqueous [Co(tren)(X)(OH₂/OH)]ⁿ⁺, [Co(cyclen)(X)(OH₂/-OH)] ⁿ⁺, and [Co(N-Mecyclen)(X)(OH₂/OH)ⁿ⁺ Systems (X = NH₃, OH₂/OH; n = 3, 2, 1)

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R.; Rogers, A. J. Inorg. Chem. 1998, 37, 4865.

(Download)

Formation of an Association Complex between Methylcobalamin and Cyanide

Brasch, N. E.; Mueller, F.; Zahl, A.; van Eldik, R.* Inorg. Chem. 1997, 36, 4891.

(Download)

Evidence for the Unexpected Associative Displacement of Adenosyl by Cyanide in Coenzyme B₁₂

Brasch, N. E.; Hamza, M. S. A.; van Eldik, R.* Inorg. Chem. 1997, 36, 3216.

(Download)

Nucleophilic Catalysis by HPO₄^2- in the Hydrolysis of Cr₂O₇^2-. Formation and Decay of HO₃POCrO₃^2-

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R. Aust. J. Chem. 1994, 47, 2283.

(Download)

Hydrolysis of Cr₂O₇^2-. Nucleophilic Catalysis by TRIS and Rate Laws for the Formation and Decay of a (TRIS)CrO₃ Intermediate

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R. Inorg. Chem. 1994, 33, 2683.

(Download)

Orthophosphate Complexes of Cobalt(III), trans-[Co(en)₂(OH₂)(OPO₃H)]ClO₄10.5H₂O and its Properties in Aqueous Solution

Brasch, N. E.; Buckingham, D. A.*; Simpson, J.; Stewart, I. Inorg. Chem. 1990, 29, 371.

(Download)

4. Origin of the Products in the Base Hydrolysis of [Co(NH₃)₅X]^(3-n)+ Complexes

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R.; Finnie, K. S. Inorg. Chem. 1989, 28, 4567.

(Download)

Stereochemical Change in the Hg²⁺-, Ag⁺-, and Cl₂-Induced and Spontaneous Reactions of Pentaamminecobalt-(III)-Acido Species: A Reexamination

Brasch, N. E.; Buckingham, D. A.*; Clark, C. R.; Finnie, K. S. Inorg. Chem. 1989, 28, 3386.

(Download)

Does downloading these PDFs take too long?

PDF is a really useful file format created by Adobe. You probably know that you need to have software installed on your computer to open these files. Adobe’s default PDF reader is free and has become kind of a standard for viewing PDF files. Unfortunately the Adobe PDF reader is a huge program that takes forever and a day to load. In other words, it’s not the downloading of PDF files that takes so long, it’s the opening of the default reader software. If that bothers you, there is an alternative free reader that you can download from Foxit. It is a very lean program and loads in virtually no time. Make sure to also get the associated plugin for your browser, which will hopefully be Firefox, since it is the best browser currently available and free! How to install Foxit and the plugin is described for example here.

Publications

Vitamin B12 and redox homeostasis: Cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)

Mechanistic Studies on the Reaction between R2N-NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl (NO-) Group from R2N-NONOates to Cobalt(III) Centers

Synthesis, Synchrotron X-ray Diffraction and Kinetic Studies on the Formation of a Novel Thiolatocobalamin of Captopril: Evidence for cis-trans isomerization in the β-axial Ligand

High Resolution Crystal Structure Determination of the Methylcobalamin Analogs Ethylcobalamin and Butylcobalamin by X-ray Synchrotron Diffraction

A Novel Role for Vitamin B12: Cobalamins are Potent Intracellular Antioxidants

Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product

NMR Spectroscopy and Molecular Modelling Studies of Nitrosylcobalamin: Further Evidence that the Deprotonated, Base-off Conformation is an Important Conformation of Nitrosylcobalamin in Solution

Accurate Assessment and Identification of Naturally Occurring Cellular Cobalamins

Vanadium-Vitamin B12 Bioconjugates as Potential Therapeutics for Treating Diabetes

Synthesis and X-ray structural characterization of tris(L-glycinato)vanadium(III) and trans-tetraquadichlorovanadium(III) chloride

Nitroxylcob(III)alamin: Synthesis and X-ray Structural Characterization

X-ray Structural Characterization of Imidazolylcobalamin and Histidinylcobalamin: Cobalamin Models for Aquacobalamin Bound to the B12 Transporter Protein Transcobalamin

Structural and Spectroscopic Evidence for Formation of Trinuclear and Tetranuclear V(III)/Carboxylate Complexes of Acetate and Related Derivatives in Aqueous Solution

A Simple, Convenient Method to Synthesize Cobalamins: Synthesis of Homocysteinylcobalamin, N-Acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, Sulfitocobalamin and Nitrocobalamin

Characterization of Novel Vanadium(III)/Acetate Clusters Formed in Aqueous Solution

Ligand Exchange on Phosphenium Ions: Reversible Exchange between Free and Coordinated Alkynes in Phosphirenium Salts

Studies on the Formation of Glutathionylcobalamin: Any Free Intracellular Aquacobalamin is Likely to be Rapidly and Irreversibly Converted to Glutathionylcobalamin

Method of synthesis of β-thiolato cobalamin nucleoside compounds

A Novel Redox Mechanism for the Glutathione-dependent Reversible Uptake of a Fungal Toxin in Cells

The Reaction Between Methylcobalamin and Cyanide Revisited

Mechanistic Insight from Activation Parameters for the Reaction between Coenzyme B12 and Cyanide: Further Evidence that Heterolytic Co-C Bond Cleavage is Solvent-Assisted

Studies on the Mechanism of the Reaction between 5′-Deoxyadenosylcobinamide and Cyanide

Synthesis, Characterization, Solution Stability and X-ray Crystal Structure of the Thiolatocobalamin γ-Glutamylcysteinylcobalamin, a Dipeptide Analog of Glutathionylcobalamin: Insights Into the Enhanced Co-S Bond Stability of the Natural Product Glutathionylcobalamin

Thermodynamic and Kinetic Studies on the Reaction between the Vitamin B12 Derivative β-(N-Methylimidazolyl)cobalamin and N-Methylimidazole: Ligand Displacement at the α Axial Site of Cobalamins

Studies on the Mechanism of the Reaction Between Coenzyme B12 and Cyanide: Direct 1H NMR Spectroscopic Evidence for a (β-5′-Deoxyadenosyl)(α-cyano)cobalamin Intermediate

A Simple, Convenient and Direct Method for Assessing the Purity of Cobalamins

Synthesis and Characterization of Isolable Thiolatocobalamin Complexes Relevant to Coenzyme B12-Dependent Ribonucleotide Triphosphate Reductase

The Second Isolable B12-Thiolate Complex, (Pentafluorophenylthiolato)cobalamin: Synthesis and Characterization

17O NMR Study of Solvent Exchange in Some Aqueous [Co(tren)(X)(OH2/OH)]n+, [Co(cyclen)(X)(OH2/-OH)] n+, and [Co(N-Mecyclen)(X)(OH2/OH)n+ Systems (X = NH3, OH2/OH; n = 3, 2, 1)

Formation of an Association Complex between Methylcobalamin and Cyanide

Evidence for the Unexpected Associative Displacement of Adenosyl by Cyanide in Coenzyme B12

Nucleophilic Catalysis by HPO42- in the Hydrolysis of Cr2O72-. Formation and Decay of HO3POCrO32-

Hydrolysis of Cr2O72-. Nucleophilic Catalysis by TRIS and Rate Laws for the Formation and Decay of a (TRIS)CrO3 Intermediate

Orthophosphate Complexes of Cobalt(III), trans-[Co(en)2(OH2)(OPO3H)]ClO410.5H2O and its Properties in Aqueous Solution

4. Origin of the Products in the Base Hydrolysis of [Co(NH3)5X](3-n)+ Complexes

Stereochemical Change in the Hg2+-, Ag+-, and Cl2-Induced and Spontaneous Reactions of Pentaamminecobalt-(III)-Acido Species: A Reexamination

Does downloading these PDFs take too long?

Vitamin B₁₂ and redox homeostasis: Cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)

Mechanistic Studies on the Reaction between R₂N-NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl (NO^-) Group from R₂N-NONOates to Cobalt(III) Centers

A Novel Role for Vitamin B₁₂: Cobalamins are Potent Intracellular Antioxidants

Vanadium-Vitamin B₁₂ Bioconjugates as Potential Therapeutics for Treating Diabetes

X-ray Structural Characterization of Imidazolylcobalamin and Histidinylcobalamin: Cobalamin Models for Aquacobalamin Bound to the B₁₂ Transporter Protein Transcobalamin

Mechanistic Insight from Activation Parameters for the Reaction between Coenzyme B₁₂ and Cyanide: Further Evidence that Heterolytic Co-C Bond Cleavage is Solvent-Assisted

Thermodynamic and Kinetic Studies on the Reaction between the Vitamin B₁₂ Derivative β-(N-Methylimidazolyl)cobalamin and N-Methylimidazole: Ligand Displacement at the α Axial Site of Cobalamins

Studies on the Mechanism of the Reaction Between Coenzyme B₁₂ and Cyanide: Direct ¹H NMR Spectroscopic Evidence for a (β-5′-Deoxyadenosyl)(α-cyano)cobalamin Intermediate

Synthesis and Characterization of Isolable Thiolatocobalamin Complexes Relevant to Coenzyme B₁₂-Dependent Ribonucleotide Triphosphate Reductase

The Second Isolable B₁₂-Thiolate Complex, (Pentafluorophenylthiolato)cobalamin: Synthesis and Characterization

¹⁷O NMR Study of Solvent Exchange in Some Aqueous [Co(tren)(X)(OH₂/OH)]ⁿ⁺, [Co(cyclen)(X)(OH₂/-OH)] ⁿ⁺, and [Co(N-Mecyclen)(X)(OH₂/OH)ⁿ⁺ Systems (X = NH₃, OH₂/OH; n = 3, 2, 1)

Evidence for the Unexpected Associative Displacement of Adenosyl by Cyanide in Coenzyme B₁₂

Nucleophilic Catalysis by HPO₄^2- in the Hydrolysis of Cr₂O₇^2-. Formation and Decay of HO₃POCrO₃^2-

Hydrolysis of Cr₂O₇^2-. Nucleophilic Catalysis by TRIS and Rate Laws for the Formation and Decay of a (TRIS)CrO₃ Intermediate

Orthophosphate Complexes of Cobalt(III), trans-[Co(en)₂(OH₂)(OPO₃H)]ClO₄10.5H₂O and its Properties in Aqueous Solution

4. Origin of the Products in the Base Hydrolysis of [Co(NH₃)₅X]^(3-n)+ Complexes

Stereochemical Change in the Hg²⁺-, Ag⁺-, and Cl₂-Induced and Spontaneous Reactions of Pentaamminecobalt-(III)-Acido Species: A Reexamination